Wilson's disease: the 60th anniversary of Walshe's article on treatment with penicillamine.
نویسندگان
چکیده
This historical review describes Professor Walshe's seminal contribution to the treatment of Wilson's disease on the 60th anniversary of his pioneering article on penicillamine, the first effective treatment for the condition.
منابع مشابه
Withdrawal of penicillamine from zinc sulphate-penicillamine maintenance therapy in Wilson's disease: promising, safe and cheap.
BACKGROUND Penicillamine, once considered the cornerstone of treatment for Wilson disease (WD), is rather expensive and toxic, and often causes neurological worsening. Zinc sulphate, aiming at the treatment of free-copper toxicosis, has emerged as effective, safe and cheap alternative. AIM To assess the effect of withdrawal of penicillamine from maintenance treatment with penicillamine and zi...
متن کاملEffect of D-penicillamine treatment on brain metabolism in Wilson's disease: a case study.
Sequential measurements of brain glucose metabolism were carried out in a patient with Wilson's disease, before and after successful treatment with D-penicillamine. They demonstrate an evolution of regional metabolism consistent with clinical improvement. The first study showed marked hypometabolism in the putamen on both sides. The second analysis showed bilateral improvement, with predominant...
متن کاملBasal Copper Excretion in Wilson's Disease.
The clinical manifestations of Wilson's disease are believed to be due to the accumulation of toxic amounts of copper within the body. The primary aim of treatment is to remove these, usually by giving chelating agents that will combine with the copper and be excreted in the urine. The most effective of these therapeutic agents is penicillamine (Walshe, 1960), and clinical improvement follows i...
متن کاملHypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease.
Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood...
متن کاملTreatment of Wilson's disease with zinc. XVII: treatment during pregnancy.
Therapy of Wilson's disease continues to evolve. In 1997, zinc acetate was added to the list of drugs approved by the Food and Drug Administration, which includes penicillamine and trientine. The mechanism of zinc's anticopper action is unique. It induces intestinal cell metallothionein, which binds copper and prevents its transfer into blood. As intestinal cells die and slough, the contained c...
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عنوان ژورنال:
- Arquivos de neuro-psiquiatria
دوره 75 1 شماره
صفحات -
تاریخ انتشار 2017